Know Your Lung Cancer Risk
Before It’s Too Late: A Case Study
Lung cancer remains the leading cause of cancer-related deaths worldwide—and it’s often detected too late. At TrueYouOmics, we’re changing that.
By combining deep proteomics with lifestyle data, we’ve built a model that predicts lung cancer risk with surprising accuracy—giving individuals and healthcare providers the insights they need to act early.
Why Early Detection Matters
Every year, over 10 million people die from cancer—and nearly half of those deaths could be avoided with better prevention and early diagnosis.
Lung cancer, in particular, is deadly because it’s usually caught at a late stage. That’s where our work comes in.
What We Did: Risk Stratification Through Proteomics
Using a dataset of over 50,000 individuals from the UK Biobank, we developed a machine learning model that classifies people into low, medium, and high-risk categories for lung cancer.
Low-risk group
0.01%
General 5-year risk
0.38%
High-risk group
1.03%
The percentages you see—0.01% (green), 0.38% (white), and 1.03% (red)—represent real-world 5-year incidence rates of lung cancer observed in our study cohort.
The white box (0.38%) shows the actual incidence in the general population, regardless of risk level.
The green box (0.01%) represents individuals our model predicted as low-risk—and they truly had an extremely low rate of developing lung cancer.
The red box (1.03%) reflects those predicted as high-risk by our model—and they were far more likely to develop the disease.
Survival Matters: What the Data Shows
Our Kaplan-Meier survival analysis reveals what this means over time:
• People in the low-risk group show almost perfect survival probability over 5 years.
• Those in the high-risk group see a noticeable decline.
Can You Trust the Model?
Yes. Here’s Why.
We validated our model rigorously.
• Time-dependent AUC stays consistently high over 5 years
• Concordance index across folds ~0.88
These are strong indicators that our model performs well—not just in theory, but in practice.
If you’re at high risk and don’t know it, chances are you’ll only be diagnosed once symptoms appear—and by then, treatment options are limited.
Knowing your risk early gives you the power to take action:
• Stop smoking (or avoid passive smoke)
• Measure radon in your home—6.7% of US homes have elevated levels
• Avoid exposure to asbestos
• Eat more fruits and vegetables (+20% risk reduction)
• Stay physically active (+20% risk reduction)
Small changes. Big difference.
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